Schedule 2 and Schedule 2N drugs require a properly executed, manually signed prescription. NO REFILLS are permitted on these orders. All other scheduled drugs may be prescribed via written or oral orders. Written prescriptions must be signed by the prescriber. A prescriber may ask an assistant to write or type the prescription but the prescriber is responsible for ensuring that all information is correct and the prescriber must sign the prescription.For more information, see 657 I.A.C. Chapter 10 - Controlled Substances.